‘I’m 47 years old chronologically; my heart is 37, left ear is 64,’ says Bryan Johnson | Health News

Tech entrepreneur Bryan Johnson has made headlines for his ambitious anti-ageing experiments. In a recent appearance on Realign podcast, he claimed that one can successfully reverse the biological age of various organs in the body. 
Johnson explained, “So right now, I’m 47 years old chronologically, but my body has hundreds of different ages. For example, my heart is 37, my diaphragm is age 18, my liver functions as the age of an 18-year-old, and my left ear is 64. So I have different ages throughout my body and once you understand those baseline ages of the organs, you can then say, now we have a situation where the heart is 37, can we get the heart to be 36 or 35? And so you try to drive the number down and you can age the heart according to the anatomy, the cells and structure, and also the function (sic).”
Do different organs in the human body age at varying rates, and what factors contribute to these differences?
Dr Palleti Siva Karthik Reddy, consultant internal medicine at Koshys Hospitals, tells , “Yes, different organs in the body age at varying rates due to multiple factors such as genetics, lifestyle, environmental influences, and the specific function and wear-and-tear of each organ.”
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The ageing of various organs in the body is influenced a combination of internal and external factors. Dr Reddy says, “The cardiovascular system, for instance, can be impacted diet, exercise, and stress, with the stiffening of arteries over time (arteriosclerosis) slowing blood flow. The lungs can age prematurely due to smoking, pollution, and a lack of physical activity, though regular exercise helps maintain lung elasticity and function. The liver, despite its remarkable regenerative abilities, can suffer from chronic alcohol use, obesity, and toxin exposure, leading to conditions like fatty liver disease or cirrhosis.” 
Cognitive decline in the brain is influenced genetics, oxidative stress, and lifestyle, but mental stimulation and a healthy diet can help slow this process, notes Dr Reddy. “Muscles and bones naturally experience age-related changes, such as sarcopenia (muscle loss) and osteoporosis (bone density reduction), but strength training and proper intake of calcium and vitamin D can mitigate these effects. Ultimately, each organ’s ageing process is shaped its cellular structure, metabolism, and the various stressors it endures over time.”

Is it scientifically possible to reverse the age of specific organs, and what evidence supports such claims?
While it is not currently possible to fully reverse the biological age of an organ, Dr Reddy highlights that evidence suggests that certain interventions can improve organ function, mimicking a ‘younger’ state. Key approaches, according to the expert, include:
Dietary Interventions
Caloric restriction and intermittent fasting have shown to improve mitochondrial function and reduce oxidative stress, slowing cellular aging in organs like the liver and heart.
Exercise
Regular aerobic and resance training has been linked to improved heart health, increased lung capacity, and delayed muscle aging.Story continues below this ad
Anti-Ageing Therapies
Senolytics: These drugs target senescent cells that accumulate with age, potentially reversing some aspects of cellular aging.
Gene Therapy: Experimental studies on telomere extension and mitochondrial repair show promise in delaying organ-specific aging.
Stem Cell Therapy: Some research suggests stem cell infusions may regenerate damaged tissues, especially in the heart and liver.
“Although promising, these interventions require further research to confirm long-term safety and efficacy,” he stresses. Story continues below this ad
DISCLAIMER: This article is based on information from the public domain and/or the experts we spoke to. Always consult your health practitioner before starting any routine.