Drinking milk ‘didn’t help’ us with lactose intolerance

There is a good chance you have lactose intolerance. You are not alone — 5,000 years ago, most humans were lactose intolerant too.
A new study published on Wednesday in the journal Nature the University of Brol and University College London researchers found that people’s ability to digest lactose became common almost 5,000 years later than the first signs of human milk consumption, which date back to around 6,000 BC.
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They also found, using new computer modeling methods, that milk consumption wasn’t the reason for the increase in lactose tolerance.
“Milk didn’t help at all,” study author Mark Thomas, a University College London researcher, told DW.
“I’m excited about the statical modeling method that we developed. As far as I’m aware, nobody’s done that before,” said Thomas.

What is lactose intolerance?
All babies can normally digest lactose. But for most of them, this ability will start to wane after they wean off breastmilk.
Today about two-thirds of people are lactase non-persent, which means they can’t digest lactose, the main sugar in milk.
People who are lactase non-persent can’t produce an enzyme called lactase, which breaks down lactose. When this enzyme is absent, lactose is free to travel to the colon, where bacteria feast on it.
This can cause unpleasant side effects, like cramps, farting or diarrhea. Together these symptoms are called lactose intolerance.
Surprising results

The results of this study are contrary to a widespread belief that our prehoric ancestors’ consumption of dairy led to the evolution of a genetic variation allowing them to digest lactose even after adulthood.
This assumption can be partly traced to the marketing of the alleged health benefits of lactose tolerance. For years, milk companies, doctors and even nutritions have peddled milk and dairy as important supplements of vitamin D and calcium and good sources of uncontaminated water.
But the researchers quickly dismissed these ideas after analyzing a huge set of DNA and medical information of people in the UK. They found that whether or not they could tolerate lactose had little effect on people’s health, their calcium levels or whether they drank milk or not, said Thomas.
Why did lactase persence evolve?
Genetic studies show that lactase persence is “the most strongly selected single gene trait to have evolved in the last 10,000 years,” said Thomas.
At around 1,000 BC, the number of humans with the capacity to digest lactose, which is encoded in one gene, started to increase rapidly.

After discovering that milk consumption was not behind this burst of growth, the researchers tested two alternative hypotheses.
One hypothesis was that when humans became exposed to more pathogens, symptoms of lactose intolerance combined with the new infectious agents could turn deadly.
“We know that pathogen exposure would have gone up over the last 10,000 years as population densities increase, as people live closer to their domestic animals,” said Thomas.
The other hypothesis had to do with famines. When the crops sowed lactose intolerant prehoric populations failed, milk and dairy products became some of their only options for nourishment.
“If you’re a healthy person, you get diarrhea. It’s embarrassing. If you are severely malnourished and you give yourself diarrhea, there’s a good chance you’re going to die,” said Thomas.
The researchers used the same computer modeling methods to examine whether these ideas could better explain the evolution of lactase persence.

“And they did, way, way better,” said Thomas. “All these theories that ultimately relate to milk use don’t seem to help.”
The study mostly focused on European populations, and more research is needed for other continents.
Unfortunately, finding ancient DNA in African countries is trickier because it’s hotter, “and heat is a big determinant of whether DNA survives,” said Thomas.
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